The U.S. Census Bureau conducts the Decennial Census every 10 years as mandated in the U.S. Constitution. Prior to the 2020 Census, this was done with manual assignments. In 2020, optimization and machine learning techniques automated the scheduling, workload assignments and management of field data collection. MOJO, an operational control system based on these techniques, provided optimization of caseloads handled by enumerators through a geographic information system. The 2020 Census resolved 99.9% of all addresses in the nation and MOJO, via assignment optimization, provided a productivity increase of over 80%. The system was developed in collaboration with Princeton Consultants as well as others in the private sector and academia.