Merck Animal Health offers veterinarians, farmers, pet owners and governments one of the widest ranges of veterinary pharmaceuticals, vaccines and health management solutions. After four years of collaboration where vision met opportunity, a portfolio of optimization and decision support applications were implemented that substantially improved biomanufacturing effectiveness. Biomanufacturing uses living organisms (i.e., viruses and bacteria) to grow active ingredients in vaccines and therapeuticals. This high-tech manufacturing process generates challenges not found in many other industries. Additionally, the high cost of equipment and labor-intensive nature of operations precluded the ability to just add capacity. Operations research was critical to meet these challenges. The initial implementation had a 30%-50% increase in the output of critical medicines in specific areas.